Santa Fe Spaghetti

Santa Fe Spaghetti recipe | Mellow Alfredo sauce and spicy salsa are perfect complements in Santa Fe Spaghetti. Add some variety to your table with this novel, flavorful dish!

When I saw this recipe in a cookbook recently, I immediately wanted to give it a try. I’m glad I did! Though it uses ingredients that we typically have on hand, it has a very different flavor than the pasta dishes we usually consume.


(Significantly adapted from the Favorite Brand Name One-Dish Recipes cookbook.)

  • 16 oz. spaghetti noodles
  • 1 tablespoon olive oil
  • 2 chicken breasts, cut into strips
  • 2 cloves garlic, minced
  • 1 teaspoon ground cumin
  • Several dashes salt and pepper
  • 1 cup diced bell pepper (color of your choice)
  • 1 medium onion, chopped
  • 1 cup salsa or pico de gallo
  • ½ cup sour cream
  • 2 cups homemade Alfredo sauce or 1 jar (16 oz.) Alfredo sauce


Prepare the spaghetti according to package directions.

Heat the oil in a large, deep skillet over medium-high heat. Add the chicken and garlic. Sprinkle with the cumin, salt, and pepper; stir-fry for 2 minutes. Add in the bell pepper, onion, and salsa. Cook over medium heat for 4 minutes. Reduce the heat to low and add the sour cream and Alfredo sauce. Simmer for 7-10 minutes or until the chicken is no longer pink in the center, stirring occasionally.

Drain the spaghetti and transfer it to serving plates. Top with the chicken mixture. Yield: 5 servings.

Santa Fe Spaghetti | Mellow Alfredo sauce and spicy salsa are perfect complements in Santa Fe Spaghetti. Add some variety to your table with this novel, flavorful dish!


I would never have thought to combine Alfredo sauce with salsa, but the flavors—the mellowness of the Alfredo sauce and the spice of the salsa—complement one another so well! It’s truly a unique flavor. It was spicy enough to please my husband’s taste buds, but mild enough that my toddler enjoyed it.

The ingredients for this dish cost approximately $7.87, which is just $1.57 per serving. If you’re looking to put something novel and flavorful on the table, give this dish a try!

Shared at the following link party:

The Art of Home-Making, Tuesdays with a Twist, Tuesday Talk, Weekend Potluck, Inspiration Spotlight, Creative Gallery, and Titus 2 Tuesday.


  1. Being such a pasta lover I find this interesting and will give it a try.. I cannot imagine salsa and Alfredo but look forward to trying it out.. Thank you..

    • Hi Faye,
      It’s a very different combo, isn’t it? The flavor is very unique…not the sort of thing I would want every week, but a nice change of pace to serve occasionally.

  2. That sounds quite delicious! I love the concept of the creaminess of alfredo sauce with the bite of salsa. And with the chicken added, I’m sure that this is marvelous!

  3. Pat Kettering says:

    Sounds good. I should try this.

  4. Yummy! I’m gonna have to make this for dinner tomorrow. I love that it has salsa in it.
    Thanks for sharing your recipe!
    Enjoy your week!
    Blessings, Amy

  5. It looks really tasty! And I love that it uses alfredo sauce. I just love it! It’s horrible for me, but it tastes so great.

  6. YUMMY!! I just finished supper and I’m ready for round two now. =)

  7. Congrats! This delectable dish caught our eye at Weekend Potluck and is being featured at this week’s party. Please come again soon. And have a great weekend.

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